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Selected Publications (original research articles or review papers):

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  1. Tan C.T., Soh JH Natalie, Chang H.C., & Yu V.C. p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities. The FEBS Journal, 2021.
     

  2. Chang H.C.; Tao R.T.; Tan C.T.; Wu Y.J.; Bay B.H.; Yu V.C. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Autophagy, 2021.
     

  3. Tan C.T.; Chang H.C; Zhou Q.L.; Yu C.D.; Fu N.Y.; Sabapathy K.; Yu V.C. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. EMBO reports, 2021, 22:e50854.
     

  4. C.H. Ang, S.H. Hsu, F. Guo, C.T. Tan, V.C. Yu, J.E. Visvader, P.K.H. Chow, N.Y. Fu, Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis, PNAS, 2019, 116:19530-19540.
     

  5. S.J. Chan, H. Zhao, K. Hayakawa, C. Chai, C.T. Tan, J. Huang, R. Tao, G. Hamanaka, T. Arumugam, E. Lo, V.C. Yu*, P.T.H. Wong*. Modulator of Apoptosis (MOAP)-1 is a potential therapeutic target in acute ischemic injury, Journal of Cerebral Blood Flow and Metabolism, 2019, 0271678X18794839. 
     

  6. H. Zhao, N. Mohamed, S.J. Chan, C.T. Tan, R. Tao, V.C. Yu, P.T.H. Wong. Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1 deficient mice, Molecular Neurobiology, 2018, 56:2185-2201.
     

  7. J. Law, I. Kwek, O. Svystun, J. Lim, C.T. Tan, L. Luong, V.C. Yu, S. Baksh. RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1). Biochim. Biophys. Acta Mol. Cell Res, 2018, 1865:684-694.
     

  8. Tan, C. T., Zhou, Q. L., Su, Y. C., Fu, N. Y., Chang, H. C., Tao, R. N., Sukumaran, S. K., Baksh, S., Tan, Y. J., Sabapathy, K., Yu, C. D. & Yu, V. C. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Cell reports, 2016, 16, 174-85.
     

  9. Yoong, S. L., Lau, W. L., Liu, A. Y., Prendergast, D., Ho, H. K., Yu, V. C., Lee, C., Ang, W. H. & Pastorin, G. Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells. Nanoscale, 2015, 7, 13907-17.
     

  10. Shelar, S. B., Kaminska, K. K., Reddy, S. A., Kumar, D., Tan, C. T., Yu, V. C., Lu, J., Holmgren, A., Hagen, T. & Chew, E. H. Thioredoxin-dependent regulation of AIF-mediated DNA damage. Free radical biology & medicine, 2015, 87, 125-36.
     

  11. Law, J., Salla, M., Zare, A., Wong, Y., Luong, L., Volodko, N., Svystun, O., Flood, K., Lim, J., Sung, M., Dyck, J. R., Tan, C. T., Su, Y. C., Yu, V. C., Mackey, J. & Baksh, S. Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein. The Journal of biological chemistry, 2015, 290, 24100-18.
     

  12. Gordon, M., El-Kalla, M., Zhao, Y., Fiteih, Y., Law, J., Volodko, N., Mohamed, A., El-Kadi, A. O., Liu, L., Odenbach, J., Thiesen, A., Onyskiw, C., Ghazaleh, H. A., Park, J., Lee, S. B., Yu, V. C., Fernandez-Patron, C., Alexander, R. T., Wine, E. & Baksh, S. Correction: the tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PloS one, 2015, 10, e0131150.
     

  13. Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation, 2014, 21, 797-810.
     

  14. Gordon, M., El-Kalla, M., Zhao, Y., Fiteih, Y., Law, J., Volodko, N., Anwar-Mohamed, A., El-Kadi, A. O., Liu, L., Odenbach, J., Thiesen, A., Onyskiw, C., Ghazaleh, H. A., Park, J., Lee, S. B., Yu, V. C., Fernandez-Patron, C., Alexander, R. T., Wine, E. & Baksh, S. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PloS one, 2013, 8, e75483.
     

  15. Arshad, M., Ye, Z., Gu, X., Wong, C. K., Liu, Y., Li, D., Zhou, L., Zhang, Y., Bay, W. P., Yu, V. C. & Li, P. RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway. The Journal of biological chemistry, 2013, 288, 8726-36.
     

  16. Zhang, L., Mei, Y., Fu, N. Y., Guan, L., Xie, W., Liu, H. H., Yu, C. D., Yin, Z., Yu, V. C. & You, H. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109, 20937-42.
     

  17. Sukumaran, S. K., Fu, N. Y., Tin, C. B., Wan, K. F., Lee, S. S. & Yu, V. C. A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis. Molecular cell, 2010, 37, 768-83.

  18. Krishnamoorthy, J., Yu, V. C. & Mok, Y. K. Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems. PloS one, 2010, 5, e8943.
     

  19. Bernardo, P. H., Sivaraman, T., Wan, K. F., Xu, J., Krishnamoorthy, J., Song, C. M., Tian, L., Chin, J. S., Lim, D. S., Mok, H. Y., Yu, V. C., Tong, J. C. & Chai, C. L. Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. Journal of medicinal chemistry, 2010, 53, 2314-8.
     

  20. Wan, K. F., Wang, S., Brown, C. J., Yu, V. C., Entzeroth, M., Lane, D. P. & Lee, M. A. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL. Cell cycle, 2009, 8, 3943-52.
     

  21. Subauste, M. C., Ventura-Holman, T., Du, L., Subauste, J. S., Chan, S. L., Yu, V. C. & Maher, J. F. RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. Cancer biology & therapy, 2009, 8, 2297-305.
     

  22. Mohd-Ismail, N. K., Deng, L., Sukumaran, S. K., Yu, V. C., Hotta, H. & Tan, Y. J. The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1. Journal of virology, 2009, 83, 9993-10006.
     

  23. Lee, S. S., Fu, N. Y., Sukumaran, S. K., Wan, K. F., Wan, Q. & Yu, V. C. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. Experimental cell research, 2009, 315, 1313-25.
     

  24. Fu, N. Y., Sukumaran, S. K., Kerk, S. Y. & Yu, V. C. Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism. Molecular cell, 2009, 33, 15-29.
     

  25. Wan, K. F., Chan, S. L., Sukumaran, S. K., Lee, M. C. & Yu, V. C. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. The Journal of biological chemistry, 2008, 283, 8423-33.
     

  26. Foley, C. J., Freedman, H., Choo, S. L., Onyskiw, C., Fu, N. Y., Yu, V. C., Tuszynski, J., Pratt, J. C. & Baksh, S. Dynamics of RASSF1A/MOAP-1 association with death receptors. Molecular and cellular biology, 2008, 28, 4520-35.
     

  27. Bernardo, P. H., Wan, K. F., Sivaraman, T., Xu, J., Moore, F. K., Hung, A. W., Mok, H. Y., Yu, V. C. & Chai, C. L. Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors. Journal of medicinal chemistry, 2008, 51, 6699-710.
     

  28. Tan, Y. X., Tan, T. H., Lee, M. J., Tham, P. Y., Gunalan, V., Druce, J., Birch, C., Catton, M., Fu, N. Y., Yu, V. C. & Tan, Y. J. Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. Journal of virology, 2007, 81, 6346-55.
     

  29. Fu, N. Y., Sukumaran, S. K. & Yu, V. C. Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104, 10051-6.
     

  30. Zhang, Y. H., Bhunia, A., Wan, K. F., Lee, M. C., Chan, S. L., Yu, V. C. & Mok, Y. K. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. Journal of molecular biology, 2006, 364, 536-49.
     

  31. Armstrong, M. B., Bian, X., Liu, Y., Subramanian, C., Ratanaproeksa, A. B., Shao, F., Yu, V. C., Kwok, R. P., Opipari, A. W., Jr. & Castle, V. P. Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma. Neoplasia, 2006, 8, 967-77.
     

  32. Tan, K. O., Fu, N. Y., Sukumaran, S. K., Chan, S. L., Kang, J. H., Poon, K. L., Chen, B. S. & Yu, V. C. MAP-1 is a mitochondrial effector of Bax. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, 14623-8.
     

  33. Baksh, S., Tommasi, S., Fenton, S., Yu, V. C., Martins, L. M., Pfeifer, G. P., Latif, F., Downward, J. & Neel, B. G. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Molecular cell, 2005, 18, 637-50.
     

  34. Chua, B. T., Volbracht, C., Tan, K. O., Li, R., Yu, V. C. & Li, P. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nature cell biology, 2003, 5, 1083-9.
     

  35. Chan, S. L., Lee, M. C., Tan, K. O., Yang, L. K., Lee, A. S., Flotow, H., Fu, N. Y., Butler, M. S., Soejarto, D. D., Buss, A. D. & Yu, V. C. Identification of chelerythrine as an inhibitor of BclXL function. The Journal of biological chemistry, 2003, 278, 20453-6.
     

  36. Wang, H., Yeo, S. L., Xu, J., Xu, X., He, H., Ronca, F., Ting, A. E., Wang, Y., Yu, V. C. & Sim, M. M. Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis. Journal of natural products, 2002, 65, 721-4.
     

  37. Tan, K. O., Tan, K. M., Chan, S. L., Yee, K. S., Bevort, M., Ang, K. C. & Yu, V. C. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. The Journal of biological chemistry, 2001, 276, 2802-7.
     

  38. Tan, K. M., Chan, S. L., Tan, K. O. & Yu, V. C. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. The Journal of biological chemistry, 2001, 276, 44193-202.
     

  39. Chan, S. L., Yee, K. S., Tan, K. M. & Yu, V. C. The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells. The Journal of biological chemistry, 2000, 275, 17925-8.
     

  40. Tan, K. O., Tan, K. M. & Yu, V. C. A novel BH3-like domain in BID is required for intramolecular interaction and autoinhibition of pro-apoptotic activity. The Journal of biological chemistry, 1999, 274, 23687-90.
     

  41. Ronca, F., Yee, K. S. & Yu, V. C. Retinoic acid confers resistance to p53-dependent apoptosis in SH-SY5Y neuroblastoma cells by modulating nuclear import of p53. The Journal of biological chemistry, 1999, 274, 18128-34.
     

  42. Chan, S. L., Tan, K. O., Zhang, L., Yee, K. S., Ronca, F., Chan, M. Y. & Yu, V. C. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. The Journal of biological chemistry, 1999, 274, 32461-8.
     

  43. Yee, K. S. & Yu, V. C. Isolation and characterization of a novel member of the neural zinc finger factor/myelin transcription factor family with transcriptional repression activity. The Journal of biological chemistry, 1998, 273, 5366-74.
     

  44. Ronca, F., Chan, S. L. & Yu, V. C. 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway. The Journal of biological chemistry, 1997, 272, 4252-4260.

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